$NVAX > $MRNA
Both vaccines elicited plasma antibodies dominated by IgG and recognized all Spike protein domains. Interestingly, RBD-specific IgG was also detected in saliva, especially in animals of the protein vaccine group, and remained detectable throughout the study, similar to what has been observed after human natural infection (28). Moreover, 7 of 8 Protein-3M-052-SE vaccinated animals had RBD-specific IgA after the 2nd immunization. Salivary RBD-specific IgG and IgA may either be mucosally produced or transudated from plasma
$PFE $MRNA $BNTX
Scientists believe the latest Indian “double mutant” variant exhibit traits that could make it more infectious and less susceptible to vaccine-induced immunity, and we may well see the virus mutate further and in a direction that will make the current batch of vaccines even less effective.
As new variants emerge, therefore, we are likely to need booster shots to maintain our levels of protection or to fight new variants.